Archive for immune function

Ramping Up Herd Health: Key Strategies for Dairy Farmers Amid Rising Feed Costs and Market Volatility

Unlock essential tactics to enhance dairy herd health in the face of escalating feed prices and an unpredictable market. Are your cows receiving the necessary nutrition for peak performance?

The U.S. dairy industry stands at a crossroads, grappling with volatile feed prices. As a significant player in the global dairy market, maintaining optimal herd health is more crucial than ever. With approximately 9.2 to 9.4 million cows, primarily located in the West, the High Plains, and Texas, the industry’s growth demands a reevaluation of health strategies. 

Investing in comprehensive herd health, including optimal nutrition and trace mineral management, ensures dairy performance and profitability. This article outlines significant health challenges for cows during the high-stress transition period and the impact of essential trace minerals on performance. 

Using outdated technology from the 1930s for modern dairy farming is impractical. Effective herd health management can reduce health issues, boost milk production, and enhance reproductive success. These insights, grounded in research and practical applications, are vital for a thriving and resilient dairy industry. For instance, modern technology, such as automated milking systems and precision feeding tools, is revolutionizing the industry.

Transition Troubles: Navigating Health Challenges in the Dairy Industry’s Most Critical Period

The most significant health challenges in the dairy industry revolve around the transition cow period, from three weeks before calving to three weeks after. This phase is crucial as cows endure high stress and are vulnerable to health issues like metritis, retained placenta, and milk fever. External factors, such as high pathogenic avian influenza outbreaks, add complexity. 

An ideal health state for a dairy cow during this period is defined by the absence of any disease or disorder—these are what we refer to as ‘no problem cows.’ These healthy cows transition seamlessly without demanding much attention. In contrast, morbid cows suffering from one or more health events require substantial focus and resources, impacting overall efficiency and productivity. 

Empowerment through Proactive Health Management: dairy farmers must recognize health issue indicators during this period. Signs like increased body temperature, loss of appetite, lethargy, and reduced milk production require proactive management practices, including close monitoring and immediate intervention. This proactive approach puts the control back in the hands of the farmers, allowing them to steer their herds toward optimal health and productivity. 

Optimism for the Future: this period challenges health and defines the cow’s future productivity. However, issues during this time can be effectively managed, leading to potential improvements in milk yield, reproductive performance, and overall longevity in the herd. Hence, investing in the health of transition cows promotes sustained productivity and profitability in dairy farming operations, instilling a sense of hope and optimism for the future. 

Addressing these challenges requires a multifaceted approach. Nutrition is pivotal, with diets supplemented with essential trace minerals like copper, zinc, and manganese to support immune function and reproductive health. Stress management strategies, including providing a comfortable environment and minimizing routine changes, can alleviate pressures on cows during this period. 

The Pillars of Ruminant Vitality: Essential Trace Minerals

Essential trace minerals for ruminant performance include copper, zinc, manganese, cobalt, and iodine. These minerals play critical roles in various physiological functions: 

  • Copper: Vital for proper immune function, enzyme activity, and overall growth.
  • Zinc: Essential for immune health, enzyme function, and skin integrity.
  • Manganese: Necessary for reproductive health, bone formation, and enzyme activity.
  • Cobalt: Important for vitamin B12 synthesis and overall metabolic function.
  • Iodine: Crucial for thyroid hormone production, which regulates metabolism.

Copper and zinc are crucial for immune health, providing the body with the strength to fight infections and maintain overall wellness. On the other hand, zinc and manganese are vital for reproductive performance, ensuring proper fertility rates and healthy offspring. 

Deficiencies in these minerals are rare due to the industry’s well-developed diets, which ensure that animals receive all the necessary nutrients for optimal health. Nevertheless, if a deficiency does occur, it typically manifests in several ways: 

  • Poor Hair Coat: A lack of essential trace minerals leads to a dull, rough haircoat.
  • Hoof Health Issues: Weakened hooves can result from insufficient trace mineral intake, leading to conditions like foot rot.
  • Reproductive Performance: Deficiencies can adversely affect fertility rates and the overall reproductive health of the animal.

A balanced diet with these essential trace minerals is vital for dairy herds’ sustained health and productivity.

Proactive Health Monitoring: The Dairy Cow’s Silent Signals

Unlike the precision alerts provided by a vehicle’s ‘check engine light,’ dairy cows present subtler signs during the critical transition period, such as incidences of metritis or milk fever, that signal underlying nutritional imbalances. The early detection of these issues is vital, as unaddressed deficiencies can progressively deteriorate overall health and performance, undermining milk production and reproductive efficiency. The insidious nature of these declines means they might not be immediately noticeable. Still, their cumulative impact can severely compromise herd productivity and economic sustainability. Farmers must be vigilant and proactive in monitoring dairy cow health, particularly during this vulnerable transition phase. Implementing routine health assessments, meticulously observing any behavioral or physical changes, and acting swiftly on any signs of distress are crucial for preventing minor issues from escalating into major health crises.

Guidance and Support: ensuring the optimal health of a dairy herd transcends regular check-ups; it necessitates a holistic, integrated approach that includes comprehensive nutrition and veterinary care. Producers can craft diets tailored explicitly to their cows’ unique requirements by collaborating closely with nutritionists and veterinarians, enhancing health and productivity. This collaborative strategy provides the necessary support and guidance, ensuring that producers are not navigating the complexities of herd health alone.

Strategic Supplementation: Navigating Seasonal Stresses with Enhanced Nutrition 

Seasonal stressors, like heat stress, require adjustments in trace mineral feeding; during heat stress, intake decreases, necessitating a more concentrated diet. Higher levels of bioavailable trace minerals, particularly zinc, are critical to helping cows cope with and recover from heat stress more effectively. Ensuring dairy cows receive adequate zinc during stressful periods is paramount as it aids their overall resilience and recovery, leading to better health outcomes. 

Trace minerals are a cost-effective investment in herd health. Supplementing with hydroxy trace minerals costs about a penny and a half to two pennies per cow per day. Despite this seeming minimal expense, the impact on the herd’s health, productivity, and longevity is substantial. For instance, research studies have consistently demonstrated the multiple benefits of proper trace mineral supplementation. These studies highlight improvements in: 

  • Health: Cows supplemented with the right trace minerals exhibit fewer health issues, including lower rates of mastitis, lameness, and metabolic disorders.
  • Milk production: A healthier cow translates directly into higher milk yields, ensuring that dairy operations remain economically viable and productive. Reproductive performance: Proper trace mineral nutrition improves reproductive outcomes, including improved conception rates and healthier calves. This is crucial for maintaining a sustainable and profitable dairy operation.

Investing in high-quality, bioavailable trace minerals, particularly hydroxy trace minerals, is a strategic move for dairy producers aiming to enhance herd health and performance. The extensive benefits outweigh the minimal cost, making it a prudent choice for managing the challenges of seasonal stressors and optimizing overall herd productivity.

Embrace Modern Solutions: Elevating Dairy Herd Health with Hydroxy Chloride Trace Minerals 

Dairy producers should embrace advancements in trace mineral technology. Modern hydroxy chloride trace minerals are more effective and bioavailable than nearly century-old sulfate trace minerals, significantly enhancing herd health and performance. 

In today’s dairy industry, a herd’s health and productivity can make the difference between profitability and financial strain. Traditional sulfate trace minerals, introduced in the 1930s, may no longer meet the demands of modern dairy cows. Hydroxy chloride trace minerals offer a more absorbable form of nutrition that fits contemporary dairy farming needs

Hydroxy chloride trace minerals have superior bioavailability and fewer antagonistic interactions in the cow’s rumen. Unlike their sulfate counterparts, these minerals are less prone to oxidation and do not form insoluble complexes. This makes more mineral content available for the cow’s metabolism, improving overall health, immune function, and reproductive performance. 

The shift to hydroxy chloride trace minerals incurs only a minimal additional cost—about a penny per cow daily. Given the substantial benefits, this slight cost increase is well worth the enhanced health and longevity of the herd. Studies show that cows supplemented with these minerals experience fewer health issues, leading to reduced veterinary costs and better lactation performance. 

Trace mineral supplementation is crucial during stress periods such as the transition phase or summer heat. Enhanced resilience against these stressors can lead to fewer disruptions in milk production and reproductive cycles, fostering a more stable and productive herd. Hydroxy chloride trace minerals’ longevity and productivity gains justify transitioning from outdated sulfate forms. 

Ultimately, dairy producers must make informed decisions that affect their animals’ well-being and their operations’ sustainability. Embracing hydroxy chloride trace minerals is a forward-thinking approach that aligns with advancements in dairy science and the evolving challenges of modern farming. This transition ensures high-performance dairy cows receive the nutrition they need to thrive.

The Bottom Line

Elevating the health of your dairy herd is critical in today’s volatile market. This article emphasizes maintaining optimal herd health, especially during the transition period. We highlight the role of trace minerals—copper, zinc, and manganese—in boosting immune health and reproduction and note the subtle deficiency signs producers must watch for. Producers can tackle health challenges by offering a balanced diet and adopting modern solutions like hydroxy chloride trace minerals. Our discussions, supported by extensive research, reveal that proactive health management is beneficial and cost-effective. Optimal herd health leads to better milk production, reproductive success, and increased cow longevity, enhancing the sustainability and profitability of dairy operations. The evidence is clear: integrating modern nutritional strategies is crucial for your herd’s welfare and dairy business. I urge all dairy producers to adopt these advanced approaches for a robust return on investment.

Key Takeaways:

  • U.S. dairy industry maintains a steady population of 9.2 to 9.4 million cows, predominantly in the West, especially the High Plains and Texas.
  • The transition period (last three weeks before calving and first three weeks of lactation) is the most critical for dairy cow health.
  • Essential trace minerals, including copper, zinc, and manganese, play significant roles in immune health and reproductive performance.
  • Deficiencies in trace minerals are rare due to well-developed diets but can manifest in physical symptoms over time.
  • Heat stress affects feed intake, necessitating more concentrated diets with higher trace mineral levels, particularly zinc, for recovery.
  • Modern advancements, such as hydroxy chloride trace minerals, offer superior bioavailability and efficacy compared to older sulfate-based options.
  • Investing in high-quality trace mineral supplements can lead to fewer health issues, longer herd longevity, and improved milk production.

Summary: 

The U.S. dairy industry faces significant health challenges during the transition cow period, which occurs three weeks before calving to three weeks after. Cows are vulnerable to issues like metritis, retained placenta, and milk fever, and external factors like high pathogenic avian influenza outbreaks add complexity. An ideal health state is defined by the absence of any disease or disorder, while morbid cows require significant focus and resources, impacting efficiency and productivity. Proactive health management is essential for dairy farmers to recognize health issue indicators during this period, allowing them to steer their herds towards optimal health and productivity. Investing in the health of transition cows promotes sustained productivity and profitability in dairy farming operations, instilling hope and optimism for the future. Nutrition is pivotal, with diets supplemented with essential trace minerals to support immune function and reproductive health. Stress management strategies, such as providing a comfortable environment and minimizing routine changes, can alleviate pressures on cows during this period.

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Enhancing Dairy Cow Health: The Power of Saccharomyces Cerevisiae Fermentation Products During Gut Challenges

Explore the transformative impact of Saccharomyces cerevisiae fermentation products on dairy cow health during gut barrier challenges. Interested in enhancing your herd’s well-being? Keep reading to uncover the advantages.

Imagine a solution that could significantly bolster the health and productivity of your dairy herd, especially during stressful periods. Saccharomyces cerevisiae fermentation products (SCFP) are emerging as a highly effective tool that not only enhances gut health but also improves the overall well-being of your lactating cows. This potent supplement can navigate the complexities of cow physiology to deliver remarkable benefits, particularly during gut barrier challenges. In this article, we will delve into the impact of SCFP on the ruminal microbiota and metabolome, presenting a comprehensive analysis of its multifaceted advantages.

Unleashing the Power of Yeast: Why Saccharomyces Cerevisiae Fermentation Products are Transforming Dairy Farming 

Saccharomyces cerevisiae fermentation products (SCFP) are yeast-based supplements that enhance dairy cow health and performance through a range of metabolites and bioactive compounds. Used extensively in dairy farming, these products are known for their numerous benefits. 

SCFP improve digestive efficiency by stabilizing the ruminal environment, which optimizes feed breakdown and fermentation. This leads to better nutrient absorption and overall health. 

Additionally, SCFP strengthen immune function by enhancing gut integrity and reducing gut-related ailments. This is particularly valuable during stressful periods like calving or environmental changes. 

Incorporating Saccharomyces cerevisiae fermentation products in dairy diets is a scientifically proven method to boost digestion, nutrient uptake, and immune resilience, ultimately enhancing the health and productivity of dairy herds.

The Comprehensive Study on Gut Microbiota and Metabolomics Amid Stress

The study on lactating Holstein cows evaluated the impacts of Saccharomyces cerevisiae fermentation products (SCFP) during a gut barrier challenge. Two groups of multiparous cows were involved—one as a control (CON) and another receiving 19 grams per day of SCFP (SCFP group). Over nine weeks, followed by a five-day feed restriction (FR) where cows were fed just 40% of their usual intake, the researchers explored the effects on ruminal microbiota and metabolomic profiles under stress.

Researchers used cutting-edge techniques to understand SCFP’s effects on the cows. They extracted DNA from ruminal fluid samples and performed PacBio full-length 16S rRNA gene sequencing for a detailed microbial profile. Real-time PCR then quantified 12 key ruminal bacterial species to zero in on specific microbial populations. 

Metabolomic analysis involved examining up to 189 metabolites in the ruminal fluid via gas chromatography-mass spectrometry (GC/MS). High-quality sequences were analyzed using advanced software like TADA, MicrobiomeAnalyst, PICRUSt2, and STAMP to explore microbial diversity and metabolic functions. MetaboAnalyst 5.0 helped interpret the data, revealing complex interactions between microbiota and metabolic pathways during stress.

A Deep Dive into Microbial Diversity and Enhanced Metabolic Profiles with SCFP Supplementation

The study revealed significant insights into the influence of Saccharomyces cerevisiae fermentation products (SCFP) during gut barrier challenges in lactating Holstein cows. Notably, the SCFP group exhibited an increase in microbial diversity within the ruminal fluid, indicated by higher α-diversity Chao 1 and Shannon indices. This suggests a more varied and resilient microbial ecosystem, crucial during stress. Additionally, specific bacterial genera like CPla_4_termite_groupCandidatus SaccharimonasOribacterium, and Pirellula were more abundant in cows given SCFP. These bacteria are linked to beneficial processes, enhancing rumen health. Higher levels of key metabolites such as ethanolamine, glyoxylic acid, serine, and threonine were also found, highlighting positive metabolic shifts induced by SCFP.

Revealing the Metabolic Influence: SCFP’s Role in Enhancing Key Biological Processes

In our metabolite analysis, we noted significant increases in the SCFP group compared to the control. Specifically, ethanolamine, glyoxylic acid, serine, threonine, cytosine, and stearic acid levels rose. These metabolites are crucial for the health and productivity of dairy cows

SCFP also influenced the pentose phosphate and photorespiration pathways. The pentose phosphate pathway enhances fatty acid and nucleotide synthesis, indicating improved anabolic processes in the SCFP group. 

The photorespiration pathway, more common in plants, seems to help cows adapt to feed restriction stress, promoting metabolic balance and energy production under suboptimal conditions. 

In addition, we found a higher abundance of Fretibacterium and Succinivibrio, which correlated positively with multiple metabolites like galactose, fructose, and alanine. This increase indicates enhanced microbial activity and metabolic function. 

Overall, feeding SCFP during feed restriction shifted the ruminal microbiota composition and function, supporting pathways that boost resilience and productivity under stress. This highlights SCFP’s potential as a dietary intervention to enhance dairy cow health and performance.

Boosting Resilience and Productivity: Practical Implications for Dairy Farmers 

As dairy farmers, maintaining the health and productivity of your cows, especially during stress periods like feed restriction, is crucial. Our study shows that adding Saccharomyces cerevisiae fermentation products (SCFP) to your cows’ diets can offer significant benefits.  

Incorporating SCFP helps your cows maintain a healthier gut barrier, improving digestive health during stressful times when feed intake is restricted. This enhancement in ruminal microbiota diversity and metabolic profiles supports better nutrient absorption and overall gut function.  

For your herd, this means less disruption to milk production and cow health during stress periods. Beneficial metabolites like ethanolamine, serine, and stearic acid support gut health and essential physiological functions.  

Introducing SCFP into your cows’ diet can boost resilience to stress by enhancing metabolic pathways like the pentose phosphate pathway and photorespiration, which improve energy production and reduce oxidative stress.  

Start gradually with the recommended SCFP dosage, monitor improvements in health and production, and consult a nutritionist if needed. By strategically using SCFP, you can help your cows thrive even under challenging conditions.

The Bottom Line

Supplementing Saccharomyces cerevisiae fermentation products (SCFP) during gut barrier challenges offers significant benefits to dairy cows. SCFP enhances ruminal microbiota diversity, supports key metabolic pathways, and boosts cows’ resilience and productivity under stress.  

This study shows that SCFP supplementation increases important metabolic processes like the pentose phosphate pathway and photorespiration. It also fosters a more diverse microbial environment, leading to better gut health and overall physiological robustness.  

For dairy farmers, incorporating SCFP into the feed regimen can dramatically improve herd health and productivity. SCFP helps mitigate stress effects, promoting a healthy gut microbiome, which translates to better milk production and farm performance.  

Consider the solid evidence for SCFP supplementation. It’s a scientifically proven method to enhance cow health and boost farm sustainability and profitability. Investing in SCFP might be the step that sets your dairy operation apart.  

The science behind SCFP is complex, but its benefits are clear. Healthier cows lead to a healthier farm. Embracing SCFP can have lasting positive impacts on herd well-being and productivity. As we strive to improve dairy farming practices, innovative feed solutions like SCFP are essential. 

Key Takeaways:

  • Saccharomyces cerevisiae fermentation products (SCFP) improve the health of dairy cows by modulating the gut microbiota, especially during stress periods such as feed restriction.
  • Feeding SCFP to lactating Holstein cows resulted in greater microbial diversity and distinct metabolite profiles in the rumen.
  • Enhanced concentrations of beneficial metabolites like ethanolamine, serine, and stearic acid were observed in cows supplemented with SCFP.
  • Key metabolic pathways, including the pentose phosphate pathway and photorespiration pathway, were upregulated by SCFP, suggesting improved metabolic efficiency.
  • SCFP supplementation led to the predominance of beneficial bacteria like Fretibacterium and Succinivibrio, which are associated with various positive biological processes.
  • The study highlights significant shifts from the tricarboxylic acid cycle to the glyoxylate cycle in cows fed SCFP, enhancing nitrogenous base production.
  • Dairy farmers can leverage SCFP to boost cow resilience and productivity by supporting better gut health and metabolic functions.

Summary:

Saccharomyces cerevisiae fermentation products (SCFP) are a yeast-based supplement that can significantly improve dairy herd health and productivity during stressful periods. SCFP stabilizes the ruminal environment, optimizes feed breakdown and fermentation, and enhances digestive efficiency, nutrient absorption, and overall health. It strengthens immune function by enhancing gut integrity and reducing gut-related ailments, especially during stressful periods like calving or environmental changes. A study on lactating Holstein cows showed that SCFP increased microbial diversity within the ruminal fluid, promoting a more diverse and resilient microbial ecosystem. Specific bacterial genera like CPla_4_termite_group, Candidatus Saccharimonas, Oribacterium, and Pirellula were more abundant in cows given SCFP, which are linked to beneficial processes. SCFP also influenced pentose phosphate and photorespiration pathways, promoting metabolic balance and energy production under suboptimal conditions. In conclusion, SCFP during feed restriction shifts the ruminal microbiota composition and function, supporting pathways that boost resilience and productivity under stress.

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Decoding the Impact of Housing Systems on Digital Dermatitis in Dairy Cows: A Genetic Study

Delve into the influence of housing systems on digital dermatitis in dairy cows. Could genetic evaluations pave the way for enhanced bovine health across varied living conditions? Uncover the research insights here.

Imagine walking barefoot on gravel daily; the discomfort of digital dermatitis (DD) in dairy cows feels similar. This painful hoof disease significantly hampers cows’ mobility, milk production, and the economic health of dairy farms. 

The environment in which cows are housed plays a critical role in DD’s incidence and severity. Housing systems such as conventional cubicle barns (CON) and compost-bedded pack barns (CBPB) have distinct impacts on disease management. Understanding these housing-related nuances is vital for farmers and researchers working to reduce DD’s impact. 

This research utilizes detailed phenotyping data from over 2,980 observations of Holstein-Friesian and Fleckvieh-Simmental cows on ten farms. It investigates the genetic variances linked to DD stages: sick, acute, and chronic. Through genome-wide association studies (GWAS), the study identifies potential candidate genes and assesses genotype × housing system interactions. This comprehensive analysis seeks to uncover genetic factors that can inform breeding programs and enhance animal welfare, regardless of their rearing environment. 

Introduction: Understanding Digital Dermatitis in Dairy Cows

Digital Dermatitis (DD) is an infectious disease impacting the bovine foot, particularly the plantar skin bordering the interdigital cleft. This condition ranges from initial lesions to chronic, painful wounds, affecting dairy cows‘ mobility and well-being. 

The development of DD involves a mix of environmental, genetic, and management factors. Housing systems, especially conventional cubicle barns, create conditions ripe for DD, with moisture and contamination fostering pathogen growth. Nutritional imbalances, poor foot hygiene, and milking routines further increase risk. Notably, genetic predispositions also play a role; some cattle lines are more susceptible, emphasizing the need for genetic research to combat DD. 

The economic and welfare impacts of DD are significant. Economically, it causes losses through reduced milk production, higher veterinary costs, and culling of severely affected cows. Welfare-wise, the pain and lameness from DD seriously affect cattle comfort and health, raising ethical concerns in livestock management. Therefore, addressing DD with better housing, management practices, and genetic selection is crucial for sustainable dairy farming.

Exploring Housing Systems: Cubicle Barns vs. Compost-Bedded Pack Barns

Housing systems play a pivotal role in dairy productivity and cow health and welfare. The primary systems include conventional cubicle barns (CON) and compost-bedded pack barns (CBPB), each impacting the Prevalence and severity of digital dermatitis (DD). 

In CON setups, cows rest on mats or mattresses over concrete floors. This controlled environment supports restful ruminating but can worsen claw disorders due to constant exposure to manure and poor ventilation. Conversely, CBPB systems offer cows a spacious environment with composting bedding of sawdust or wood shavings, which is more comfortable and supports better hoof health by reducing pathogens through microbial activity. 

The flooring material is crucial. Concrete floors in CON systems retain moisture and manure, fostering bacteria that cause DD. CBPB systems’ drier, more sanitary bedding leads to fewer DD incidences. 

Hygiene practices, essential for DD control, differ by system. CON systems require regular scraping and washing, while CBPB systems depend on managing bedding moisture and microbial activity. Both approaches aim to reduce bacterial loads and curb DD spread. 

Cow comfort, dictated by the housing system, also affects DD prevalence. CBPB’s spacious, free-roaming environment reduces stress and improves immune function, making cows less prone to DD. In contrast, CON systems’ restrictiveness can increase anxiety and susceptibility to claw disorders. 

In summary, the choice between cubicle barns and compost-bedded pack barns significantly impacts cow health and the incidence of DD. Prioritizing comfort and hygiene in housing systems leads to healthier, more productive cows with fewer claw disorders.

Unveiling Genetic Interactions Between Housing Systems and Digital Dermatitis in Dairy Cows

ParameterConventional Cubicle Barns (CON)Compost-Bedded Pack Barns (CBPB)Overall Dataset
Number of Observations1,4501,5302,980
Number of Cows8118991,710
DD-Sick Prevalence (%)HigherLower20.47%
DD-Acute Prevalence (%)HigherLower13.88%
DD-Chronic Prevalence (%)HigherLower5.34%
Heritability – DD-Sick0.160.160.16
Heritability – DD-Acute0.140.140.14
Heritability – DD-Chronic0.110.110.11
Genetic Correlation (CON and CBPB) – Same Traits~0.80N/A
Genetic Correlation – Within Traits (DD-Sick, DD-Acute, DD-Chronic)0.58 – 0.81
Significant Candidate Genes for DD-Sick and DD-Acute (SNP Main Effects)METTL25, AFF3, PRKG1, TENM4
Significant Candidate Genes (SNP × Housing System Interaction)ASXL1, NOL4L (BTA 13)

The genetic study on digital dermatitis (DD) in dairy cows examined the influence of different housing systems on the disease. This research aimed to understand the interaction between cow genotypes and their environments. It focused on DD stages—DD-sick, DD-acute, and DD-chronic—in conventional cubicle barns (CON) and compost-bedded pack barns (CBPB). Herds were selected to ensure similarities in climate, feeding, and milking systems. Still, they differed in housing setups to isolate housing-specific impacts on DD. 

Using 2,980 observations from 1,710 cows and 38,495 SNPs from 926 genotyped cows after quality control, the study employed single-step approaches for single-trait repeatability animal models and bivariate models to estimate genetic parameters and correlations. GWAS identified specific SNPs and their interactions with housing systems. Heritabilities for DD stages and genetic correlations between the same traits in different housing systems were also calculated. 

Results showed higher DD prevalence in CON systems compared to CBPB. Heritabilities were 0.16 for DD-sick, 0.14 for DD-acute, and 0.11 for DD-chronic, with a slight increase in CON. Genetic correlations between the same DD traits in different housing systems were around 0.80, indicating minimal genotype × housing system interactions. Correlations among DD stages ranged from 0.58 to 0.81, showing their interconnectedness regardless of the housing system. 

GWAS results were varied for DD-acute and DD-chronic, indicating complex pathogenesis. Candidate genes affecting disease resistance or immune response included METTL25, AFF3, PRKG1, and TENM4 for DD-sick and DD-acute. SNP × housing system interactions highlighted ASXL1 and NOL4L on BTA 13 for DD-sick and DD-acute. 

For dairy farmers, these findings underline the impact of housing systems on the Prevalence and progression of DD and the potential genetic implications. Our comprehensive study provides actionable insights for dairy farmers globally. 

Notably, DD prevalence was significantly higher in CON, highlighting the challenging environment of cubicle barns compared to the more welfare-oriented CBPB system. These insights are crucial as they affect animal health and have economic ramifications, including reduced milk production and increased treatment costs. 

We examined genetic evaluations across these environments and found that heritabilities for DD traits (DD-sick, DD-acute, DD-chronic) were slightly higher in the CON system. Still, overall genetic parameters remained consistent across both systems. Despite different housing practices, the genetic predisposition to DD remains relatively stable. 

Genetic correlations between different DD stages (ranging from 0.58 to 0.81) suggest a common underlying genetic resistance mechanism crucial for developing targeted breeding programs. Furthermore, GWAS pinpointed several candidate genes, such as METTL25, AFF3, PRKG1, and TENM4, with significant implications for disease resistance and immunology. 

This research underscores the importance of genotype-environment interactions, even though these were minimal in housing systems. Integrating genomic insights with practical management strategies can improve animal well-being and farm productivity as the dairy industry evolves. 

By applying these findings, dairy farmers can make informed decisions about housing systems and genetic selection, enhancing economic and animal health outcomes. This study calls for the industry to adopt evidence-based practices rooted in rigorous scientific research.

Genetic Evaluations: From Genotypes to Phenotypes

The research meticulously analyzed data from 1,311 Holstein-Friesian and 399 Fleckvieh-Simmental cows, totaling 2,980 observations across three digital dermatitis (DD) stages: DD-sick, DD-acute, and DD-chronic. This granular phenotyping clarifies how DD stages manifest in different environments. By categorizing it into conventional cubicle barns (CON) and compost-bedded pack barns (CBPB), the study highlights the environmental impact on genetic expressions related to DD. 

Quality control of 50K SNP genotypes refined the data to 38,495 SNPs from 926 cows. This dataset formed the basis for estimating genetic parameters through single-step approaches. The genetic correlations between DD traits and housing systems uncovered genotype × environment (G×E) interactions. 

Heritability estimates were 0.16 for DD-sick, 0.14 for DD-acute, and 0.11 for DD-chronic, indicating the genetic influence. Notably, these estimates and genetic variances slightly rose in the more stressful CON environment, indicating heightened genetic differentiation under challenging conditions. Genetic correlations between the same DD traits across different housing systems were around 0.80, showing minimal G×E interactions. 

Genome-wide association studies (GWAS) revealed heterogeneous Manhattan plots for DD-acute and DD-chronic traits, indicating complex biological pathways. Despite this, several shared candidate genes like METTL25, AFF3, PRKG1, and TENM4 were identified, showing their potential role in managing DD through genetic selection. 

For SNP × housing system interactions, genes such as ASXL1 and NOL4L on chromosome 13 were relevant for DD-sick and DD-acute. These findings illustrate how specific genetic markers interact with environmental factors. Overall, the minimal impact of genotype × housing system interactions supports robust genetic evaluations for DD across diverse environments, aiding broader genetic selection strategies in dairy cow populations. 

The Bottom Line

This study highlights the importance of detailed phenotyping and genetic evaluations in understanding digital dermatitis (DD) in dairy cows. By examining 1,710 Holstein-Friesian and Fleckvieh-Simmental cows in conventional cubicle barns (CON) and compost-bedded pack barns (CBPB), the research provided crucial insights into the Prevalence and heritability of DD. It found slightly higher genetic differentiation in the more challenging CON environment but minimal genotype × housing system interactions, indicating a limited impact on genetic assessments. Essential genes like METTL25, AFF3, PRKG1, and TENM4 were identified as necessary for disease resistance and immunology. 

Understanding how housing systems affect DD is crucial. It helps improve management practices to reduce DD prevalence, enhancing cow welfare and farm productivity. It also improves genetic selection by identifying traits that enhance DD resistance in specific environments, benefiting long-term herd health and sustainability. This insight is vital for today’s dairy operations and future breeding programs. 

Future research should delve into the long-term impact of housing systems on genetic traits linked to DD resistance. Exploring other environmental and management factors, like nutrition and milking routines, would offer a fuller understanding of DD. Personalized genetic interventions tailored to specific farm environments could be a game-changer in managing this disease in dairy cows.

Key Takeaways:

  • The study analyzed 2,980 observations of DD stages, differentiating between DD-sick, DD-acute, and DD-chronic across two housing systems: conventional cubicle barns (CON) and compost-bedded pack barns (CBPB).
  • Heritabilities for DD were slightly higher in the CON environment, suggesting a stronger genetic differentiation of the disease in more challenging conditions.
  • Despite varying heritabilities, genetic correlations between the same DD traits in different housing systems were high, indicating minimal genotype × housing system interactions.
  • GWAS highlighted significant candidate genes such as METTL25, AFF3, and PRKG1, which play roles in disease resistance and immunology.
  • This research underscores the importance of considering housing systems in genetic evaluations to enhance disease management and improve cow welfare.


Summary: Digital Dermatitis (DD) is a severe hoof disease that affects dairy cows’ mobility, milk production, and farm economic health. Housing systems like conventional cubicle barns (CON) and compost-bedded pack barns (CBPB) have distinct impacts on disease management. CON setups, which support restful ruminating but can worsen claw disorders due to constant exposure to manure and poor ventilation, have higher DD-sick prevalence than CBPB systems (5.34%). Both approaches aim to reduce bacterial loads and curb DD spread. CBPB’s spacious, free-roaming environment reduces stress and improves immune function, making cows less prone to DD. A study found higher DD prevalence in CON systems compared to CBPB. Understanding how housing systems affect DD is crucial for improving management practices, enhancing cow welfare, and improving genetic selection.

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